RT Journal Article
SR Electronic
T1 Nuclear Imaging in Metastatic Paraganglioma
JF Journal of Nuclear Medicine Technology
JO J. Nucl. Med. Technol.
FD Society of Nuclear Medicine
SP 251
OP 252
DO 10.2967/jnmt.116.180067
VO 44
IS 4
A1 Rohit Kedia
A1 Neil Hansen
A1 Whitney Goldner
YR 2016
UL http://tech.snmjournals.org/content/44/4/251.abstract
AB Paragangliomas associated with mutations of the SDHD gene can occasionally result in distant metastasis. Diagnosis can be difficult, and nuclear imaging is used to evaluate the case further. Not all tumors are alike; nuclear avidity may differ. We present a case in which metastatic paraganglioma caused by mutations of the SDHD gene was negative on 123I-metaiodobenzylguanidine scintigraphy and positive on 111In-labeled octreotide scintigraphy. This situation presents an opportunity for a novel therapeutic approach toward metastatic paraganglioma using targeted peptide receptor radionuclide therapy.