PT  - JOURNAL ARTICLE
AU  - Kedia, Rohit
AU  - Hansen, Neil
AU  - Goldner, Whitney
TI  - Nuclear Imaging in Metastatic Paraganglioma
AID  - 10.2967/jnmt.116.180067
DP  - 2016 Dec 01
TA  - Journal of Nuclear Medicine Technology
PG  - 251--252
VI  - 44
IP  - 4
4099  - http://tech.snmjournals.org/content/44/4/251.short
4100  - http://tech.snmjournals.org/content/44/4/251.full
SO  - J. Nucl. Med. Technol.2016 Dec 01; 44
AB  - Paragangliomas associated with mutations of the SDHD gene can occasionally result in distant metastasis. Diagnosis can be difficult, and nuclear imaging is used to evaluate the case further. Not all tumors are alike; nuclear avidity may differ. We present a case in which metastatic paraganglioma caused by mutations of the SDHD gene was negative on 123I-metaiodobenzylguanidine scintigraphy and positive on 111In-labeled octreotide scintigraphy. This situation presents an opportunity for a novel therapeutic approach toward metastatic paraganglioma using targeted peptide receptor radionuclide therapy.