RT Journal Article
SR Electronic
T1 Diuretic Renal Scintigraphy in Patients with Sulfonamide Allergies: Possible Alternative Use of Ethacrynic Acid
JF Journal of Nuclear Medicine Technology
JO J. Nucl. Med. Technol.
FD Society of Nuclear Medicine
SP 239
OP 241
DO 10.2967/jnmt.115.161331
VO 43
IS 4
A1 Nguyen, Ba D.
A1 Roarke, Michael C.
A1 Young, Jason Robert
A1 Yang, Ming
A1 Osborn, Howard H.
YR 2015
UL http://tech.snmjournals.org/content/43/4/239.abstract
AB Furosemide may trigger life-threatening sulfonamide cross-hypersensitivity reactions, posing a dilemma in patients who need diuretic renal scintigraphy. Methods: We present our experience using ethacrynic acid as a nonsulfonamide alternative diuretic in 5 patients, with a discussion of the diuretic molecular structure, potential side effects, protocol development, and imaging results. Results: Diuretic renal scintigraphy using ethacrynic acid provided useful information about the obstruction status in all patients, with no adverse clinical impact. Conclusion: Ethacrynic acid is a potential alternative to furosemide for patients with severe sulfonamide reactions.