PT - JOURNAL ARTICLE AU - Ba D. Nguyen AU - Michael C. Roarke AU - Jason Robert Young AU - Ming Yang AU - Howard H. Osborn TI - Diuretic Renal Scintigraphy in Patients with Sulfonamide Allergies: Possible Alternative Use of Ethacrynic Acid AID - 10.2967/jnmt.115.161331 DP - 2015 Dec 01 TA - Journal of Nuclear Medicine Technology PG - 239--241 VI - 43 IP - 4 4099 - http://tech.snmjournals.org/content/43/4/239.short 4100 - http://tech.snmjournals.org/content/43/4/239.full SO - J. Nucl. Med. Technol.2015 Dec 01; 43 AB - Furosemide may trigger life-threatening sulfonamide cross-hypersensitivity reactions, posing a dilemma in patients who need diuretic renal scintigraphy. Methods: We present our experience using ethacrynic acid as a nonsulfonamide alternative diuretic in 5 patients, with a discussion of the diuretic molecular structure, potential side effects, protocol development, and imaging results. Results: Diuretic renal scintigraphy using ethacrynic acid provided useful information about the obstruction status in all patients, with no adverse clinical impact. Conclusion: Ethacrynic acid is a potential alternative to furosemide for patients with severe sulfonamide reactions.