PT  - JOURNAL ARTICLE
AU  - Aydin, Funda
AU  - Budak, Evrim Surer
AU  - Demirelli, Serkan
AU  - Oner, Ali Ozan
AU  - Korkmaz, Selen
AU  - Suleymanlar, Gultekin
AU  - Akbas, Halide
AU  - Davran, Fatih
AU  - Gungor, Firat
TI  - Comparison of Cystatin C and β-Trace Protein Versus <sup>99m</sup>Tc-DTPA Plasma Sampling in Determining Glomerular Filtration Rate in Chronic Renal Disease
AID  - 10.2967/jnmt.115.154799
DP  - 2015 Sep 01
TA  - Journal of Nuclear Medicine Technology
PG  - 206--213
VI  - 43
IP  - 3
4099  - http://tech.snmjournals.org/content/43/3/206.short
4100  - http://tech.snmjournals.org/content/43/3/206.full
SO  - J. Nucl. Med. Technol.2015 Sep 01; 43
AB  - Glomerular filtration rate (GFR) is the best indicator of renal function. The gold standard for GFR measurement is inulin clearance. However, its measurement is inconvenient, time-consuming, and costly. Thus, in both scientific studies and routine clinical practice nuclear medicine methods (99mTc-diethylenetriaminepentaacetic acid [99mTc-DTPA] and 51Cr-ethylenediaminetetraacetic acid [51Cr-EDTA]) are preferred, and they correlate strongly with inulin clearance. In addition, cystatin C and β-trace protein have also recently been used for this purpose. In the literature, however, data are limited about the clinical value of cystatin C and β-trace protein in GFR measurement in chronic renal disease (CRD), and the results have been inconclusive. In this study, we aimed to determine the efficiency of cystatin C and β-trace protein in the determination of GFR in CRD patients. Methods: Eighty-four patients with CRD were included in the study (59 men and 25 women; age range, 21–88 y; mean age, 61 y). GFR was calculated using the gold-standard 99mTc-DTPA 2-sample plasma sampling method (TPSM) and 2 alternative methods: a formula using cystatin C and a formula using β-trace protein. The correlation between TPSM and the cystatin C and β-trace protein methods was assessed, and Bland–Altman analysis was used to graph scatterplots of the differences at a confidence interval of 95% (mean difference ± 1.96 SDs). Results: GFRs calculated using both alternative methods correlated strongly with those calculated using the gold standard. However, the correlation was stronger for the cystatin C method than for the β-trace protein method, and neither method produced reliably consistent GFRs. Conclusion: This study demonstrated that cystatin C and β-trace protein do not reflect GFR with sufficient accuracy.