TY - JOUR T1 - The Effect of Cyclosporine on Technetium-99m Red Blood Cell Labeling Using the Ultratag® RBC In Vitro Kit JF - Journal of Nuclear Medicine Technology JO - J. Nucl. Med. Technol. SP - 22 LP - 25 VL - 23 IS - 1 AU - Alan D. Gleue AU - Jay A. Spicer AU - David F. Preston Y1 - 1995/03/01 UR - http://tech.snmjournals.org/content/23/1/22.abstract N2 - Objective: The purpose of this investigation is to determine if cyclosporine (CsA) interferes with Technetium-99m red blood cell (99mTc-RBC) labeling when using the Ultratag® in vitro RBC kit. Methods: The investigators set up a dilution study using increasing cyclosporine concentrations with whole blood samples. Whole blood samples from four heart transplant patients on maintenance CsA medication were also radiolabeled to investigate labeling efficiencies. Results: Cyclosporine did not interfere with 99mTc-RBC radiolabeling as labeling efficiencies were found to be ≥95% in both the dilution and patient studies. Conclusions: Although CsA does not inhibit 99mTc-RBC radiolabeling of whole blood when using the Ultratag kit, the investigators hypothesize that CsA may interfere with the label if kit levels of stannous ion were to be decreased. ER -