RT Journal Article
SR Electronic
T1 The Effect of Cyclosporine on Technetium-99m Red Blood Cell Labeling Using the Ultratag® RBC In Vitro Kit
JF Journal of Nuclear Medicine Technology
JO J. Nucl. Med. Technol.
FD Society of Nuclear Medicine
SP 22
OP 25
VO 23
IS 1
A1 Alan D. Gleue
A1 Jay A. Spicer
A1 David F. Preston
YR 1995
UL http://tech.snmjournals.org/content/23/1/22.abstract
AB Objective: The purpose of this investigation is to determine if cyclosporine (CsA) interferes with Technetium-99m red blood cell (99mTc-RBC) labeling when using the Ultratag® in vitro RBC kit. Methods: The investigators set up a dilution study using increasing cyclosporine concentrations with whole blood samples. Whole blood samples from four heart transplant patients on maintenance CsA medication were also radiolabeled to investigate labeling efficiencies. Results: Cyclosporine did not interfere with 99mTc-RBC radiolabeling as labeling efficiencies were found to be ≥95% in both the dilution and patient studies. Conclusions: Although CsA does not inhibit 99mTc-RBC radiolabeling of whole blood when using the Ultratag kit, the investigators hypothesize that CsA may interfere with the label if kit levels of stannous ion were to be decreased.