PT  - JOURNAL ARTICLE
AU  - Alan D. Gleue
AU  - Jay A. Spicer
AU  - David F. Preston
TI  - The Effect of Cyclosporine on Technetium-99m Red Blood Cell Labeling Using the Ultratag® RBC In Vitro Kit
DP  - 1995 Mar 01
TA  - Journal of Nuclear Medicine Technology
PG  - 22--25
VI  - 23
IP  - 1
4099  - http://tech.snmjournals.org/content/23/1/22.short
4100  - http://tech.snmjournals.org/content/23/1/22.full
SO  - J. Nucl. Med. Technol.1995 Mar 01; 23
AB  - Objective: The purpose of this investigation is to determine if cyclosporine (CsA) interferes with Technetium-99m red blood cell (99mTc-RBC) labeling when using the Ultratag® in vitro RBC kit. Methods: The investigators set up a dilution study using increasing cyclosporine concentrations with whole blood samples. Whole blood samples from four heart transplant patients on maintenance CsA medication were also radiolabeled to investigate labeling efficiencies. Results: Cyclosporine did not interfere with 99mTc-RBC radiolabeling as labeling efficiencies were found to be ≥95% in both the dilution and patient studies. Conclusions: Although CsA does not inhibit 99mTc-RBC radiolabeling of whole blood when using the Ultratag kit, the investigators hypothesize that CsA may interfere with the label if kit levels of stannous ion were to be decreased.