@article {Gleue22, author = {Alan D. Gleue and Jay A. Spicer and David F. Preston}, title = {The Effect of Cyclosporine on Technetium-99m Red Blood Cell Labeling Using the Ultratag{\textregistered} RBC In Vitro Kit}, volume = {23}, number = {1}, pages = {22--25}, year = {1995}, publisher = {Society of Nuclear Medicine}, abstract = {Objective: The purpose of this investigation is to determine if cyclosporine (CsA) interferes with Technetium-99m red blood cell (99mTc-RBC) labeling when using the Ultratag{\textregistered} in vitro RBC kit. Methods: The investigators set up a dilution study using increasing cyclosporine concentrations with whole blood samples. Whole blood samples from four heart transplant patients on maintenance CsA medication were also radiolabeled to investigate labeling efficiencies. Results: Cyclosporine did not interfere with 99mTc-RBC radiolabeling as labeling efficiencies were found to be >=95\% in both the dilution and patient studies. Conclusions: Although CsA does not inhibit 99mTc-RBC radiolabeling of whole blood when using the Ultratag kit, the investigators hypothesize that CsA may interfere with the label if kit levels of stannous ion were to be decreased.}, issn = {0091-4916}, URL = {https://tech.snmjournals.org/content/23/1/22}, eprint = {https://tech.snmjournals.org/content/23/1/22.full.pdf}, journal = {Journal of Nuclear Medicine Technology} }