RT Journal Article SR Electronic T1 Radiochemical Evaluation of Commercial Iminodiacetate Hepatobiliary Radiopharmaceuticals JF Journal of Nuclear Medicine Technology JO J. Nucl. Med. Technol. FD Society of Nuclear Medicine SP 185 OP 187 VO 9 IS 4 A1 Walter Majewski A1 A. Michael Zimmer A1 Stewart M. Spies A1 John Hingeveld YR 1981 UL http://tech.snmjournals.org/content/9/4/185.abstract AB The radiochemical purity of commercially available hepatobiliary iminodiacetate radiopharmaceuticals was evaluated up to 24-hr postformulation. We used a rapid miniaturized chromatography system consisting of Gelman ITLC-SA and 20% NaCl to evaluate free pertechnetate and Gelman ITLC-SG and distilled water to evaluate hydrolyzed reduced Tc-99m (Tc-HR). Results indicate that minimal radiopharmaceutical breakdown occurred in all IDA agents tested within 5-hr post-formulation. At 8 hr after preparation, some breakdown was observed in specific IDA radiopharmaceuticals as evidenced by increasing pertechnetate levels. Greater radiopharmaceutical instability was observed at 24-hr postformulation. Tc-HR levels remained relatively low (<5%) for all IDA agents throughout the study.