TY - JOUR T1 - Radiochemical Evaluation of Commercial Iminodiacetate Hepatobiliary Radiopharmaceuticals JF - Journal of Nuclear Medicine Technology JO - J. Nucl. Med. Technol. SP - 185 LP - 187 VL - 9 IS - 4 AU - Walter Majewski AU - A. Michael Zimmer AU - Stewart M. Spies AU - John Hingeveld Y1 - 1981/12/01 UR - http://tech.snmjournals.org/content/9/4/185.abstract N2 - The radiochemical purity of commercially available hepatobiliary iminodiacetate radiopharmaceuticals was evaluated up to 24-hr postformulation. We used a rapid miniaturized chromatography system consisting of Gelman ITLC-SA and 20% NaCl to evaluate free pertechnetate and Gelman ITLC-SG and distilled water to evaluate hydrolyzed reduced Tc-99m (Tc-HR). Results indicate that minimal radiopharmaceutical breakdown occurred in all IDA agents tested within 5-hr post-formulation. At 8 hr after preparation, some breakdown was observed in specific IDA radiopharmaceuticals as evidenced by increasing pertechnetate levels. Greater radiopharmaceutical instability was observed at 24-hr postformulation. Tc-HR levels remained relatively low (<5%) for all IDA agents throughout the study. ER -