PT  - JOURNAL ARTICLE
AU  - Walter Majewski
AU  - A. Michael Zimmer
AU  - Stewart M. Spies
AU  - John Hingeveld
TI  - Radiochemical Evaluation of Commercial Iminodiacetate Hepatobiliary Radiopharmaceuticals
DP  - 1981 Dec 01
TA  - Journal of Nuclear Medicine Technology
PG  - 185--187
VI  - 9
IP  - 4
4099  - http://tech.snmjournals.org/content/9/4/185.short
4100  - http://tech.snmjournals.org/content/9/4/185.full
SO  - J. Nucl. Med. Technol.1981 Dec 01; 9
AB  - The radiochemical purity of commercially available hepatobiliary iminodiacetate radiopharmaceuticals was evaluated up to 24-hr postformulation. We used a rapid miniaturized chromatography system consisting of Gelman ITLC-SA and 20% NaCl to evaluate free pertechnetate and Gelman ITLC-SG and distilled water to evaluate hydrolyzed reduced Tc-99m (Tc-HR). Results indicate that minimal radiopharmaceutical breakdown occurred in all IDA agents tested within 5-hr post-formulation. At 8 hr after preparation, some breakdown was observed in specific IDA radiopharmaceuticals as evidenced by increasing pertechnetate levels. Greater radiopharmaceutical instability was observed at 24-hr postformulation. Tc-HR levels remained relatively low (<5%) for all IDA agents throughout the study.