PT - JOURNAL ARTICLE AU - Majewski, Walter AU - Zimmer, A. Michael AU - Spies, Stewart M. AU - Hingeveld, John TI - Radiochemical Evaluation of Commercial Iminodiacetate Hepatobiliary Radiopharmaceuticals DP - 1981 Dec 01 TA - Journal of Nuclear Medicine Technology PG - 185--187 VI - 9 IP - 4 4099 - http://tech.snmjournals.org/content/9/4/185.short 4100 - http://tech.snmjournals.org/content/9/4/185.full SO - J. Nucl. Med. Technol.1981 Dec 01; 9 AB - The radiochemical purity of commercially available hepatobiliary iminodiacetate radiopharmaceuticals was evaluated up to 24-hr postformulation. We used a rapid miniaturized chromatography system consisting of Gelman ITLC-SA and 20% NaCl to evaluate free pertechnetate and Gelman ITLC-SG and distilled water to evaluate hydrolyzed reduced Tc-99m (Tc-HR). Results indicate that minimal radiopharmaceutical breakdown occurred in all IDA agents tested within 5-hr post-formulation. At 8 hr after preparation, some breakdown was observed in specific IDA radiopharmaceuticals as evidenced by increasing pertechnetate levels. Greater radiopharmaceutical instability was observed at 24-hr postformulation. Tc-HR levels remained relatively low (<5%) for all IDA agents throughout the study.