RT Journal Article
SR Electronic
T1 An Anthropomorphic Phantom Study of Brain Dopamine Transporter SPECT Images Obtained Using Different SPECT/CT Devices and Collimators
JF Journal of Nuclear Medicine Technology
JO J. Nucl. Med. Technol.
FD Society of Nuclear Medicine
SP 41
OP 46
DO 10.2967/jnmt.114.149401
VO 43
IS 1
A1 Akira Maebatake
A1 Maho Sato
A1 Ruriko Kagami
A1 Yasuo Yamashita
A1 Isao Komiya
A1 Kazuhiko Himuro
A1 Shingo Baba
A1 Masayuki Sasaki
YR 2015
UL http://tech.snmjournals.org/content/43/1/41.abstract
AB The aim of this study was to evaluate differences in dopamine transporter SPECT images among different SPECT/CT devices and to determine the most appropriate region of interest (ROI) for semiquantitative evaluation. Methods: An anthropomorphic striatal phantom was filled with 123I solutions of different striatum-to-background radioactivity ratios. Data were acquired using 2 SPECT/CT devices equipped with low- to medium-energy general-purpose and low-energy high-resolution (LEHR) collimators. The SPECT images were reconstructed by filtered backprojection with both attenuation and scatter correction and then were analyzed using specific binding ratio (SBR). The most appropriate of 7 ROI types was determined, and we then compared the linearity and recovery of SBR among the different SPECT/CT devices and collimators. Results: The linearity of SBR was excellent for all types of ROIs. The ROI contouring the striatum based on the CT images showed the best recovery of SBR using mean activity in the striatal ROI (SBRmean) (47.8%). For this ROI, the recovery of SBRmean for SPECT/CT with a LEHR collimator with thick septa and a long hole length was 61.6%—significantly higher than that of other devices. Conclusion: The ROI contouring the striatum based on CT images was considered appropriate for evaluating dopamine transporter SPECT/CT. Among the different SPECT/CT devices, an LEHR collimator designed for 123II imaging is recommended.