TY - JOUR T1 - Reproducibility of Technetium-99m Mebrofenin Hepatic Functional Parameters Obtained with Semi-Automatic Software JF - Journal of Nuclear Medicine Technology JO - J. Nucl. Med. Technol. SP - 228 LP - 231 VL - 19 IS - 4 AU - Jeffry Spackman AU - Marjorie E. Bartlett AU - LeeAnn Ryals AU - Marsha Eklem AU - Susan Gilbert AU - Shakuntala Krishnamurthy AU - Gerbail T. Krishnamurthy Y1 - 1991/12/01 UR - http://tech.snmjournals.org/content/19/4/228.abstract N2 - The reliability of quantitative measurement of two hepatobiliary functional parameters using semi-automatic computer software was tested for reproducibility within and between institutions in an academic and a community hospital. Hepatic extraction fraction (HEF) and excretion half-time (t½) values in ten normal controls and eleven patients were determined independently by two technologists from the same institution and one technologist from a different institution. HEF and excretion t½ values were obtained using semi-automatic nuclear hepatology software and were then compared using the paired t-test to determine their reproducibility. There was no difference in the HEF or excretion t½, values obtained independently by the three technologists. We conclude that results obtained using semi-automatic computer software for quantitative nuclear hepatology with technetium-99m IDA agents are highly reproducible and should be used routinely as a supplement to hepatobiliary imaging studies. ER -