PT  - JOURNAL ARTICLE
AU  - Spackman, Jeffry
AU  - Bartlett, Marjorie E.
AU  - Ryals, LeeAnn
AU  - Eklem, Marsha
AU  - Gilbert, Susan
AU  - Krishnamurthy, Shakuntala
AU  - Krishnamurthy, Gerbail T.
TI  - Reproducibility of Technetium-99m Mebrofenin Hepatic Functional Parameters Obtained with Semi-Automatic Software
DP  - 1991 Dec 01
TA  - Journal of Nuclear Medicine Technology
PG  - 228--231
VI  - 19
IP  - 4
4099  - http://tech.snmjournals.org/content/19/4/228.short
4100  - http://tech.snmjournals.org/content/19/4/228.full
SO  - J. Nucl. Med. Technol.1991 Dec 01; 19
AB  - The reliability of quantitative measurement of two hepatobiliary functional parameters using semi-automatic computer software was tested for reproducibility within and between institutions in an academic and a community hospital. Hepatic extraction fraction (HEF) and excretion half-time (t½) values in ten normal controls and eleven patients were determined independently by two technologists from the same institution and one technologist from a different institution. HEF and excretion t½ values were obtained using semi-automatic nuclear hepatology software and were then compared using the paired t-test to determine their reproducibility. There was no difference in the HEF or excretion t½, values obtained independently by the three technologists. We conclude that results obtained using semi-automatic computer software for quantitative nuclear hepatology with technetium-99m IDA agents are highly reproducible and should be used routinely as a supplement to hepatobiliary imaging studies.