RT Journal Article
SR Electronic
T1 Dynamic Graded Subtraction: A Simple Method to Background Correct and Display Multicompartmental Radiopharmaceutical Scintigrams
JF Journal of Nuclear Medicine Technology
JO J. Nucl. Med. Technol.
FD Society of Nuclear Medicine
SP 121
OP 124
VO 13
IS 3
A1 Tuscan, Michael J.
A1 Wahl, Richard L.
A1 Botti, James
YR 1985
UL http://tech.snmjournals.org/content/13/3/121.abstract
AB A common procedure to enhance the localization of a poorly localized radiopharmaceutical is to mimic and subtract its undesirable component with a second radionuclide of a different photopeak that is physiologic nonspecific. Determination of the exact amount of the nonspecific radionuclide to subtract in a single step, however, is difficult. We describe the use of a simple method to enhance an image of a poorly localized radiopharmaceutical by incrementally subtracting another image of a specific radiopharmaceutical that mimics the objectionable image data and displays the corrected image series in cinematic mode. This method of image correction and dynamic display may be useful for a variety of procedures in which there is a significant nonspecific component of the radiotracer such as in radiolabeled antibodies, or to perform selective compartmental or organ subtraction in the case of a mixed specificity radiopharmaceutical.