PT  - JOURNAL ARTICLE
AU  - Tuscan, Michael J.
AU  - Wahl, Richard L.
AU  - Botti, James
TI  - Dynamic Graded Subtraction: A Simple Method to Background Correct and Display Multicompartmental Radiopharmaceutical Scintigrams
DP  - 1985 Sep 01
TA  - Journal of Nuclear Medicine Technology
PG  - 121--124
VI  - 13
IP  - 3
4099  - http://tech.snmjournals.org/content/13/3/121.short
4100  - http://tech.snmjournals.org/content/13/3/121.full
SO  - J. Nucl. Med. Technol.1985 Sep 01; 13
AB  - A common procedure to enhance the localization of a poorly localized radiopharmaceutical is to mimic and subtract its undesirable component with a second radionuclide of a different photopeak that is physiologic nonspecific. Determination of the exact amount of the nonspecific radionuclide to subtract in a single step, however, is difficult. We describe the use of a simple method to enhance an image of a poorly localized radiopharmaceutical by incrementally subtracting another image of a specific radiopharmaceutical that mimics the objectionable image data and displays the corrected image series in cinematic mode. This method of image correction and dynamic display may be useful for a variety of procedures in which there is a significant nonspecific component of the radiotracer such as in radiolabeled antibodies, or to perform selective compartmental or organ subtraction in the case of a mixed specificity radiopharmaceutical.