PT  - JOURNAL ARTICLE
AU  - Herzog, Sharon A.
AU  - Jacobson, Arnold F.
TI  - Comparison of Quantitative Ventilation-Perfusion Lung Scan Results Using Different Xenon-133 Ventilation Images
DP  - 1995 Dec 01
TA  - Journal of Nuclear Medicine Technology
PG  - 258--261
VI  - 23
IP  - 4
4099  - http://tech.snmjournals.org/content/23/4/258.short
4100  - http://tech.snmjournals.org/content/23/4/258.full
SO  - J. Nucl. Med. Technol.1995 Dec 01; 23
AB  - Objective: This paper evaluates the influence of the specific 133Xe ventilation images used to calculate differential function in quantitative ventilation-perfusion lung scans. Methods: Whole-lung differentials were determined on 43 133Xe ventilation/99mTc-macroaggregated albumin perfusion studies. Ventilation calculations were performed for the first-breath, up to three equilibrium and the composite of all equilibrium images, and perfusion calculations were performed for the anterior and posterior images and their geometric mean. Differences of ≥5% between comparable images were considered significant. Results: The first-breath ventilation differential differed from at least one equilibrium view in 13 patients (30%) and from the composite of all equilibrium images in seven patients (16%), while the posterior perfusion differential differed from the anterior differential in 15 patients (35%) and from the geometric mean differential in six patients (14%). By comparison, the posterior or geometric mean perfusion differential differed from either the first-breath or composite ventilation differential in 31 patients (72%). Nine patients (21 %) had ventilation/perfusion discrepancies ≥10%, with ventilation differentials more symmetric in seven patients. Conclusion: The choice of 133Xe ventilation image has only a limited effect on differential calculations. Discrepancies are more frequent between ventilation and perfusion differentials, making it important to determine both, particularly in patients with asymmetric lung disease.