TY - JOUR T1 - Rapid Quality Control of Technetium-99m-Tetrofosmin: Comparison of Miniaturized and Standard Chromatography Systems JF - Journal of Nuclear Medicine Technology JO - J. Nucl. Med. Technol. SP - 186 LP - 189 VL - 23 IS - 3 AU - Monica C. Geyer AU - A. Michael Zimmer AU - William G. Spies AU - Stewart M. Spies AU - Robert C. Hendel Y1 - 1995/09/01 UR - http://tech.snmjournals.org/content/23/3/186.abstract N2 - Objective: In this paper, we evaluate the use of miniaturized ITLC-SG strips (10 cm x 1 cm) with the same solvent system of methylene chloride:acetone (65:35) to reduce the time required to perform the quality control procedure for 99mTc-tetrofosmin. The potential problems inherent in the standard chromatography system were investigated as to the magnitude of their effects on the miniaturized system. Methods: The migration of the radiochemical components of 99mTc-tetrofosmin was evaluated using multiple miniature and standard strip sizes. Following optimization of the miniaturized system, radiochemical purity evaluations were performed simultaneously on 112 99mTc-tetrofosmin preparations using both chromatography systems and the radiochemical purity results compared. Results: Initially, similar migration of radiochemical components was found using both chromatography systems. Results of the radiochemical purity evaluations of 99mTc-tetrofosmin preparations were similar with both chromatography methods, with a mean difference of 1.3% ± 1.5%. Differences in radiochemical purity results between the two chromatography systems were less than 2% in the majority of samples. In no instance was a preparation acceptable with one chromatography system and not acceptable with the other. Conclusion: The results indicate that the miniaturized chromatography system is as effective in evaluating the radiochemical purity of 99mTc-tetrofosmin as the standard quality control procedure, with a substantial reduction in the time required to perform the procedure. ER -