PT  - JOURNAL ARTICLE
AU  - Monica C. Geyer
AU  - A. Michael Zimmer
AU  - William G. Spies
AU  - Stewart M. Spies
AU  - Robert C. Hendel
TI  - Rapid Quality Control of Technetium-99m-Tetrofosmin: Comparison of Miniaturized and Standard Chromatography Systems
DP  - 1995 Sep 01
TA  - Journal of Nuclear Medicine Technology
PG  - 186--189
VI  - 23
IP  - 3
4099  - http://tech.snmjournals.org/content/23/3/186.short
4100  - http://tech.snmjournals.org/content/23/3/186.full
SO  - J. Nucl. Med. Technol.1995 Sep 01; 23
AB  - Objective: In this paper, we evaluate the use of miniaturized ITLC-SG strips (10 cm x 1 cm) with the same solvent system of methylene chloride:acetone (65:35) to reduce the time required to perform the quality control procedure for 99mTc-tetrofosmin. The potential problems inherent in the standard chromatography system were investigated as to the magnitude of their effects on the miniaturized system. Methods: The migration of the radiochemical components of 99mTc-tetrofosmin was evaluated using multiple miniature and standard strip sizes. Following optimization of the miniaturized system, radiochemical purity evaluations were performed simultaneously on 112 99mTc-tetrofosmin preparations using both chromatography systems and the radiochemical purity results compared. Results: Initially, similar migration of radiochemical components was found using both chromatography systems. Results of the radiochemical purity evaluations of 99mTc-tetrofosmin preparations were similar with both chromatography methods, with a mean difference of 1.3% ± 1.5%. Differences in radiochemical purity results between the two chromatography systems were less than 2% in the majority of samples. In no instance was a preparation acceptable with one chromatography system and not acceptable with the other. Conclusion: The results indicate that the miniaturized chromatography system is as effective in evaluating the radiochemical purity of 99mTc-tetrofosmin as the standard quality control procedure, with a substantial reduction in the time required to perform the procedure.