RT Journal Article
SR Electronic
T1 Measuring Metabolic Function with PET: Technical Considerations
JF Journal of Nuclear Medicine Technology
JO J. Nucl. Med. Technol.
FD Society of Nuclear Medicine
SP 176
OP 180
VO 23
IS 3
A1 Brown, Terry F.
A1 Yasillo, Nicholas J.
A1 Chou, Jason
A1 Metz, John T.
A1 Chen, Chin-Tu
A1 Cooper, Malcolm D.
YR 1995
UL http://tech.snmjournals.org/content/23/3/176.abstract
AB Objective: The purpose of this study was to determine the magnitude of methodologic errors when PET is used for the quantitative measurement of regional cerebral glucose metabolism (rCMRglu). Methods: Performance of the analytic tests, which are the variables in the quantitative measurement of rCMRglu with PET, was evaluated. Results: For the scanner we evaluated, failure to perform daily calibration factor calculations was the single largest source of error. In addition, any variation in the accuracy or precision of patient plasma sample pipetting or plasma glucose level determinations, will result in corresponding changes in rCMRglu. Conclusions: Quantitative measurement of rCMRglu with PET requires close attention to laboratory skills, especially proper operation and maintenance of pipettes.