PT  - JOURNAL ARTICLE
AU  - Cheng, Kenneth T.
AU  - Brown, Barry M.
AU  - Sheppard, Mary Stewart
AU  - Xue, Fang-Ping
TI  - A Study of the Preparation of Disofenin and Gluceptate Cold-Unit Doses
DP  - 1992 Mar 01
TA  - Journal of Nuclear Medicine Technology
PG  - 33--35
VI  - 20
IP  - 1
4099  - http://tech.snmjournals.org/content/20/1/33.short
4100  - http://tech.snmjournals.org/content/20/1/33.full
SO  - J. Nucl. Med. Technol.1992 Mar 01; 20
AB  - This study evaluated the feasibility of preparing cold-unit doses (CUDs) of disofenin (DISIDA) and gluceptate (GHA) in syringe form. DISIDA and GHA reagent kits were reconstituted with normal saline and divided into single-unit doses (UDs) in accordance with the recommended volume of the manufacturers. These UDs were immediately frozen at –10°C after preparation. After 5, 10, 12, 24, and 31 days of storage, 4 CUDs from the DISIDA group were randomly selected and radiolabeled with technetium-99m (99mTc) pertechnetate. The CUDs from the GHA group were similarly radiolabeled after 7, 16, 22, and 38 days of storage. Radiochemical impurities of these 99mTc-labeled CUDs were determined and analyzed. The DISIDA CUDs produced 99mTc-DISIDA CUDs with acceptable radiochemical purity (90%) for up to 31 days but the GHA CUDs produced acceptable 99mTc-GHA CUDs only up to 16 days.