PT  - JOURNAL ARTICLE
AU  - Hung, Joseph C.
AU  - Wilson, Mark E.
AU  - Brown, Manuel L.
TI  - Rapid Preparation and Quality Control of Technetium-99m MAG3™
DP  - 1991 Sep 01
TA  - Journal of Nuclear Medicine Technology
PG  - 176--179
VI  - 19
IP  - 3
4099  - http://tech.snmjournals.org/content/19/3/176.short
4100  - http://tech.snmjournals.org/content/19/3/176.full
SO  - J. Nucl. Med. Technol.1991 Sep 01; 19
AB  - Technetium-99m mertiatide (99mTc-MAG3) is a newly approved radiopharmaceutical with a renal clearance similar to iodine-131 O-iodohippurate. The radiolabeling of 99mTc requires a 10-min heating period in a boiling water bath and an additional 8–10 min for determining radiochemical purity with a relatively expensive Sep-Pak C18 cartridge. A microwave oven heating method is an effective way to reduce the heating time (13 sec) while maintaining excellent labeling efficiency for 99mTc-MAG3 (average 99%). A two-strip minipaper chromatography system with 1:1:2 chloroform/acetone/tetrahydrofuran and 0.9% NaCl as mobile phases is a simple and rapid (2–3 min) procedure for the routine quality control of 99mTc-MAG3. The preparation and quality control of 99mTc-MAG3 can be completed within 5 min with the combination of the microwave oven heating method and the mini-paper chromatography system.