PT  - JOURNAL ARTICLE
AU  - Wieseler, Joseph F.
AU  - Gebhard, Mark W.
AU  - Hung, Joseph C.
AU  - Mullan, Brian P.
AU  - Wilson, Mark E.
TI  - In Vivo Comparison of Anticoagulant Citrate Dextrose Versus Heparin for Use as an Anticoagulant with the UltraTag<sup>®</sup> Red Blood Cell Kit
DP  - 1994 Sep 01
TA  - Journal of Nuclear Medicine Technology
PG  - 178--181
VI  - 22
IP  - 3
4099  - http://tech.snmjournals.org/content/22/3/178.short
4100  - http://tech.snmjournals.org/content/22/3/178.full
SO  - J. Nucl. Med. Technol.1994 Sep 01; 22
AB  - Objective: The package insert for the UltraTag® RBC kit recommends the use of either heparin or anticoagulant citrate dextrose (ACD) as an anticoagulant. A comparison study between heparin and ACD solution was done to assess image quality. Methods: Fourteen patients’ red blood cells (RBC) were labeled with the UltraTag® RBC kit and 99mTc using 10 units of heparin or 0.15 ml of ACD solution-A per ml of blood. The labeling efficiency (LE) of the 99mTc-labeled RBC was determined before and after reinjection, and multigated acquisition (MUGA) and whole-body images were subsequently obtained. Results: The images were analyzed by comparing the heart-to-background ratio, heart-to-lung ratio and kidney-to-background ratio. Both heparin and ACD gave similar LE and ratios of regions of interest. Conclusion: There was no significant difference between ACD and heparin groups in overall image quality either on MUGA or on visual inspection of whole-body images.