PT  - JOURNAL ARTICLE
AU  - Hart, Blaine
AU  - Sorenson, James F.
AU  - Eisenberg, Brian
AU  - Glactz, George
AU  - Owens, Deborah
AU  - Hladik, William B.
AU  - Curry, Mary C.
TI  - Radiopharmacy: Delayed Skin Rash Following Administration of Technetium-99m Diphosphonate: A Case Report
DP  - 1989 Dec 01
TA  - Journal of Nuclear Medicine Technology
PG  - 184--185
VI  - 17
IP  - 4
4099  - http://tech.snmjournals.org/content/17/4/184.short
4100  - http://tech.snmjournals.org/content/17/4/184.full
SO  - J. Nucl. Med. Technol.1989 Dec 01; 17
AB  - We report a case of a 48-yr-old woman who developed a delayed skin rash following intravenous (i.v.) administration of technetium-99m hydroxymethylene diphosphonate (99mTc-HDP). The rash was characterized by skin biopsy, and it was concluded that the reaction was due to the diphosphonate compound. The rash resolved spontaneously without treatment. With most 99mTc-based agents, adverse reactions are considered rare and are usually allergic in nature, but the delayed nature of this reaction is more common with diphosphonate compounds than with other radiopharmaceuticals. If a repeat examination is required, alternative agents (such as 99mTc-pyrophosphate) or any other diagnostic modality (magnetic resonance imaging) may be considered. An intradermal skin test may be helpful to determine the safest alternative bone agent.