RT Journal Article
SR Electronic
T1 Tumor Imaging with I-131 Labeled F(ab’)<sub>2</sub> Fragments of Monoclonal Antibodies
JF Journal of Nuclear Medicine Technology
JO J. Nucl. Med. Technol.
FD Society of Nuclear Medicine
SP 113
OP 114
VO 11
IS 3
A1 Romanelli-Beardsley, Michelle A.
A1 Moldofsky, Philip J.
A1 Mulhern, Charles B.
YR 1983
UL http://tech.snmjournals.org/content/11/3/113.abstract
AB Using radiolabeled F(ab’)2 fragments of monoclonal antibody associated with a noncirculating cell surface antigen of colon carcinoma, we have demonstrated preferential localization in small deposits of human colon carcinoma. (Images show tumor deposition without background subtraction.) Biologic distribution of the F(ab’)2 fragments is also evaluated. In 16 patients studied to date, tumor deposits as small as 1.5 cm have been readily visualized on unprocessed images without background subtraction. Optimal imaging time (tumors best defined) is 72-96 hr postadministration.