RT Journal Article
SR Electronic
T1 Imaging Considerations for a Technetium-99m Myocardial Perfusion Agent
JF Journal of Nuclear Medicine Technology
JO J. Nucl. Med. Technol.
FD Society of Nuclear Medicine
SP 6
OP 10
VO 14
IS 1
A1 English, Robert J.
A1 Jones, Alun G.
A1 Davison, Alan
A1 Lister-James, John
A1 Campbell, Stephen
A1 Holman, B. Leonard
YR 1986
UL http://tech.snmjournals.org/content/14/1/6.abstract
AB Myocardial perfusion imaging with 201 Tl chloride suffers from a number of physical, geometric, and dosimetric constraints that could be diminished if an agent labeled with 99mTc were available. The cationic complex 99mTc hexakis-(t-butylisonitrile)technetium(I) ([99mTc]TBI) has been shown to concentrate in the myocardial tissue of both animals and humans, with preliminary clinical studies demonstrating a number of technical attributes not possible with 201 Tl. Technetium-99m-TBI is a promising myocardial imaging agent that may permit high quality planar, gated, and tomographic imaging of both myocardial ischemia and infarction with reduced imaging times and improved resolution.