RT Journal Article
SR Electronic
T1 Effect of Circulating Aluminum on the Biodistribution of Tc-99m-Sn-Diphosphonate in Rats
JF Journal of Nuclear Medicine Technology
JO J. Nucl. Med. Technol.
FD Society of Nuclear Medicine
SP 160
OP 161
VO 8
IS 3
A1 Jaresko, George S.
A1 Zimmer, A. Michael
A1 Pavel, Dan G.
A1 Spies, Stewart M.
YR 1980
UL http://tech.snmjournals.org/content/8/3/160.abstract
AB The effect of varying plasma aluminum concentrations, ranging from 0 to 60 μg/ml aluminum, on the altered biodistribution of Tc-99m-Sn-diphosphonate was determined experimentally in rats. The results indicate that plasma aluminum levels of 20 μg/ml or greater result in increased soft tissue uptake of the radiopharmaceutical. This soft tissue uptake was predominantly liver and kidney. The higher plasma aluminum levels investigated (20 μg/ml or greater), which can cause an altered biodistribution of Tc-99m-Sn-diphosphonate in rats, can be found clinically in patients in a nuclear medicine department.