PT  - JOURNAL ARTICLE
AU  - Jaresko, George S.
AU  - Zimmer, A. Michael
AU  - Pavel, Dan G.
AU  - Spies, Stewart M.
TI  - Effect of Circulating Aluminum on the Biodistribution of Tc-99m-Sn-Diphosphonate in Rats
DP  - 1980 Sep 01
TA  - Journal of Nuclear Medicine Technology
PG  - 160--161
VI  - 8
IP  - 3
4099  - http://tech.snmjournals.org/content/8/3/160.short
4100  - http://tech.snmjournals.org/content/8/3/160.full
SO  - J. Nucl. Med. Technol.1980 Sep 01; 8
AB  - The effect of varying plasma aluminum concentrations, ranging from 0 to 60 μg/ml aluminum, on the altered biodistribution of Tc-99m-Sn-diphosphonate was determined experimentally in rats. The results indicate that plasma aluminum levels of 20 μg/ml or greater result in increased soft tissue uptake of the radiopharmaceutical. This soft tissue uptake was predominantly liver and kidney. The higher plasma aluminum levels investigated (20 μg/ml or greater), which can cause an altered biodistribution of Tc-99m-Sn-diphosphonate in rats, can be found clinically in patients in a nuclear medicine department.