RT Journal Article SR Electronic T1 Impurities in a 99mTc Lung Imaging Kit JF Journal of Nuclear Medicine Technology JO J. Nucl. Med. Technol. FD Society of Nuclear Medicine SP 28 OP 31 VO 5 IS 1 A1 McLean, J. R. A1 Wise, Paul YR 1977 UL http://tech.snmjournals.org/content/5/1/28.abstract AB We investigated the nature and significance of three radiochemical impurities that were found in a lung imaging kit using 99mTc-tin-macroaggregated albumin. The most abundant radiochemical impurity was a soluble 99mTc-labeled protein. Free pertechnetate (99mTcO4–) and reduced and hydrolyzed technetium (99mTcO2) were present in relatively low radioconcentrations. The presence of a soluble 99mTc-labeled protein in the preparation at the time of injection modified the biologic performance of the product. We suggest that, to be meaningful, a quality control program must employ assay procedures which are capable of identifying and quantitating all the significant radiochemical impurities that are present in a preparation.