PT  - JOURNAL ARTICLE
AU  - McLean, J. R.
AU  - Wise, Paul
TI  - Impurities in a <sup>99m</sup>Tc Lung Imaging Kit
DP  - 1977 Mar 01
TA  - Journal of Nuclear Medicine Technology
PG  - 28--31
VI  - 5
IP  - 1
4099  - http://tech.snmjournals.org/content/5/1/28.short
4100  - http://tech.snmjournals.org/content/5/1/28.full
SO  - J. Nucl. Med. Technol.1977 Mar 01; 5
AB  - We investigated the nature and significance of three radiochemical impurities that were found in a lung imaging kit using 99mTc-tin-macroaggregated albumin. The most abundant radiochemical impurity was a soluble 99mTc-labeled protein. Free pertechnetate (99mTcO4–) and reduced and hydrolyzed technetium (99mTcO2) were present in relatively low radioconcentrations. The presence of a soluble 99mTc-labeled protein in the preparation at the time of injection modified the biologic performance of the product. We suggest that, to be meaningful, a quality control program must employ assay procedures which are capable of identifying and quantitating all the significant radiochemical impurities that are present in a preparation.