RT Journal Article SR Electronic T1 Practical Generator Kinetics JF Journal of Nuclear Medicine Technology JO J. Nucl. Med. Technol. FD Society of Nuclear Medicine SP 21 OP 27 VO 4 IS 1 A1 Lamson, Myles A1 Hotte, Clifford E. A1 Ice, Rodney D. YR 1976 UL http://tech.snmjournals.org/content/4/1/21.abstract AB Equations describing the decay and buildup of nuclides in the 99Mo–99mTc generator are presented and discussed. The three basic time functions which describe the quantities of 99Mo, 99mTc, and 99Tc are then manipulated to yield time-dependent factors which simplify the calculations of generator decay. These factors are (A) the fraction of maximum 99mTc radioactivity at t hr following prior elution, (B) 99mTc radioactivity as a fraction of 99Mo radioactivity at time t following prior elution, and (C) The mole fraction of total technetium present in the generator as the metastable isomer at time t. These factors allow simple and accurate calculations of relative yields of 99mTc at different times following prior elution, expected yield in millicuries and generator elution efficiency, and total molar quantity of technetium eluted. Examples are presented. Solutions of the basic differential equations are described in detail in the Appendix.