PT  - JOURNAL ARTICLE
AU  - Ng, Cherie Wei Qi
AU  - bin Hassan, Muhammad Jai
AU  - Goh, Charles
AU  - Tong, Aaron Kian Ti
AU  - Tham, Wei Ying
AU  - Thang, Sue Ping
AU  - Lam, Winnie Wing-Chuen
AU  - Low, Han Chung
AU  - Magsombol, Butch M.
AU  - Loke, Kelvin Siu Hoong
TI  - Safety and Efficacy of <sup>90</sup>Y Selective Internal Radiation Therapy Using Glass Microspheres in Hepatocellular Carcinoma: A Southeast Asian Single-Institution Initial Experience
AID  - 10.2967/jnmt.123.265967
DP  - 2024 Jan 09
TA  - Journal of Nuclear Medicine Technology
PG  - jnmt.123.265967
4099  - http://tech.snmjournals.org/content/early/2024/01/09/jnmt.123.265967.short
4100  - http://tech.snmjournals.org/content/early/2024/01/09/jnmt.123.265967.full
AB  - Our objective was to demonstrate primarily the safety and secondarily the efficacy of 90Y glass microspheres in selective internal radiation therapy (SIRT) for hepatocellular carcinoma (HCC) in a local Southeast Asian hospital. Methods: Eleven consecutive patients with small, unresectable, nonmetastatic HCC and referred for locoregional therapy with SIRT with a curative intention were followed up for 6 mo after the procedure by way of interviews, blood tests, and anatomic scans. Results: Although 5 patients had deranged liver function tests after the procedure, in only 1 patient did this constitute a grade 1 toxicity (in alkaline phosphatase) by the Common Terminology Criteria for Adverse Events. Half the patients showed a reduction in serum α-fetoprotein measurements, and 6 of 11 patients demonstrated an objective response (complete or partial) on imaging. Conclusion: SIRT with 90Y glass microspheres is a safe and efficacious locoregional therapy for unresectable HCC. There are similar articles published in the West; however, the patient population there comprises far fewer Asians and the underlying cause for HCC is different from that in the Asian population. Despite these differences, SIRT is an equally effective and safe option for such patients.