RT Journal Article SR Electronic T1 Utility of 18F-FDG PET/CT in Assessment of Disease Extent and Response to Treatment in Xanthoma Disseminatum JF Journal of Nuclear Medicine Technology JO J. Nucl. Med. Technol. FD Society of Nuclear Medicine SP 335 OP 336 DO 10.2967/jnmt.123.266162 VO 51 IS 4 A1 Chandekar, Kunal Ramesh A1 Satapathy, Swayamjeet A1 Sharma, Ananya A1 Taneja, Neha A1 Tripathi, Madhavi A1 Bal, Chandrasekhar YR 2023 UL http://tech.snmjournals.org/content/51/4/335.abstract AB The clinical utility of 18F-FDG PET/CT is being increasingly recognized in histiocytic disorders. We report the case of a 23-y-old woman who presented with slowly progressive, yellowish-brown papules, plaques, and nodules over her face and flexures. Besides the multiple cutaneous lesions, lesions of the brain, stomach, gallbladder, and marrow were additionally revealed by baseline 18F-FDG PET/CT. Skin biopsy and the overall clinical picture were consistent with xanthoma disseminatum. Subsequent PET/CT after cladribine therapy revealed a decrease in the extent and metabolic activity of most lesions, suggestive of a favorable response. This case report highlights the potential role of 18F-FDG PET/CT in the accurate assessment of disease extent and posttreatment response in rare histiocytic disorders.