RT Journal Article
SR Electronic
T1 The Use of <sup>99m</sup>Tc-HYNIC-TOC and <sup>18</sup>F-FDG PET/CT in the Evaluation of Duodenal Neuroendocrine Tumor with Atypical and Extensive Metastasis Responding Dramatically to a Single Fraction of PRRT with <sup>177</sup>Lu-DOTATATE
JF Journal of Nuclear Medicine Technology
JO J. Nucl. Med. Technol.
FD Society of Nuclear Medicine
SP 296
OP 298
DO 10.2967/jnmt.114.139238
VO 42
IS 4
A1 Basu, Sandip
A1 Abhyankar, Amit
YR 2014
UL http://tech.snmjournals.org/content/42/4/296.abstract
AB This report describes a case of extensive diffuse bone marrow involvement with bilateral breast metastases from duodenal neuroendocrine tumor giving rise to a superscan-like appearance on somatostatin receptor–targeted 99mTc-hydrazinonicotinamide-TOC scintigraphy. The metastatic lesions demonstrated partial concordance with 18F-FDG PET/CT findings, signifying varying tumor biology and heterogeneity among metastatic lesions in the same individual, as illustrated with a dual-tracer approach. There was a dramatic symptomatic and biochemical response and better health-related quality of life with a single fraction of peptide receptor radionuclide therapy with 177Lu-DOTATATE, and radiologically there was stable disease at that point.