PT  - JOURNAL ARTICLE
AU  - Basu, Sandip
AU  - Abhyankar, Amit
TI  - The Use of <sup>99m</sup>Tc-HYNIC-TOC and <sup>18</sup>F-FDG PET/CT in the Evaluation of Duodenal Neuroendocrine Tumor with Atypical and Extensive Metastasis Responding Dramatically to a Single Fraction of PRRT with <sup>177</sup>Lu-DOTATATE
AID  - 10.2967/jnmt.114.139238
DP  - 2014 Dec 01
TA  - Journal of Nuclear Medicine Technology
PG  - 296--298
VI  - 42
IP  - 4
4099  - http://tech.snmjournals.org/content/42/4/296.short
4100  - http://tech.snmjournals.org/content/42/4/296.full
SO  - J. Nucl. Med. Technol.2014 Dec 01; 42
AB  - This report describes a case of extensive diffuse bone marrow involvement with bilateral breast metastases from duodenal neuroendocrine tumor giving rise to a superscan-like appearance on somatostatin receptor–targeted 99mTc-hydrazinonicotinamide-TOC scintigraphy. The metastatic lesions demonstrated partial concordance with 18F-FDG PET/CT findings, signifying varying tumor biology and heterogeneity among metastatic lesions in the same individual, as illustrated with a dual-tracer approach. There was a dramatic symptomatic and biochemical response and better health-related quality of life with a single fraction of peptide receptor radionuclide therapy with 177Lu-DOTATATE, and radiologically there was stable disease at that point.