RT Journal Article
SR Electronic
T1 Clinical Application of <sup>99m</sup>Tc-Pyrophosphate Scintigraphy for Diagnosis of Cardiac Amyloidosis: A Case Series
JF Journal of Nuclear Medicine Technology
JO J. Nucl. Med. Technol.
FD Society of Nuclear Medicine
SP 125
OP 128
DO 10.2967/jnmt.123.265614
VO 51
IS 2
A1 Shoura, Sami
A1 Malhotra, Saurabh
YR 2023
UL http://tech.snmjournals.org/content/51/2/125.abstract
AB Cardiac amyloidosis (CA) is an infiltrative cardiomyopathy resulting from deposition of insoluble amyloid protein in the myocardial interstitium. The accumulation of amyloid protein causes the myocardium to thicken and stiffen, leading to diastolic dysfunction and, eventually, heart failure. Two primary types of amyloidosis—transthyretin and immunoglobulin light chain—account for nearly 95% of all CA diagnoses. Three case studies are presented. The first demonstrates a patient positive for transthyretin amyloidosis, the second demonstrates a patient positive for light-chain CA, and the third demonstrates a patient showing blood-pool uptake on the [99mTc]Tc-pyrophosphate scan but negative for CA.