PT  - JOURNAL ARTICLE
AU  - Shoura, Sami
AU  - Malhotra, Saurabh
TI  - Clinical Application of <sup>99m</sup>Tc-Pyrophosphate Scintigraphy for Diagnosis of Cardiac Amyloidosis: A Case Series
AID  - 10.2967/jnmt.123.265614
DP  - 2023 Jun 01
TA  - Journal of Nuclear Medicine Technology
PG  - 125--128
VI  - 51
IP  - 2
4099  - http://tech.snmjournals.org/content/51/2/125.short
4100  - http://tech.snmjournals.org/content/51/2/125.full
SO  - J. Nucl. Med. Technol.2023 Jun 01; 51
AB  - Cardiac amyloidosis (CA) is an infiltrative cardiomyopathy resulting from deposition of insoluble amyloid protein in the myocardial interstitium. The accumulation of amyloid protein causes the myocardium to thicken and stiffen, leading to diastolic dysfunction and, eventually, heart failure. Two primary types of amyloidosis—transthyretin and immunoglobulin light chain—account for nearly 95% of all CA diagnoses. Three case studies are presented. The first demonstrates a patient positive for transthyretin amyloidosis, the second demonstrates a patient positive for light-chain CA, and the third demonstrates a patient showing blood-pool uptake on the [99mTc]Tc-pyrophosphate scan but negative for CA.