PT  - JOURNAL ARTICLE
AU  - Subramanian, Kritika
AU  - Stangl-Kremser, Judith
AU  - Sawoszczyk, Lady
AU  - Avlonitis, Vasilios
AU  - Gernerd, Andrew
AU  - Nixon, Kyla
AU  - Zgaljardic, Michael
AU  - Tagawa, Scott
AU  - Bander, Neil
AU  - Osborne, Joseph R.
TI  - α-Labeling of J591, an Antibody Targeting Prostate-Specific Membrane Antigen: The Technique and Considerations from the First Dedicated Production Lab at an Academic Institution in the United States
AID  - 10.2967/jnmt.122.265166
DP  - 2023 Apr 25
TA  - Journal of Nuclear Medicine Technology
PG  - jnmt.122.265166
4099  - http://tech.snmjournals.org/content/early/2023/04/25/jnmt.122.265166.short
4100  - http://tech.snmjournals.org/content/early/2023/04/25/jnmt.122.265166.full
AB  - The protein expression of the prostate-specific membrane antigen correlates with unfavorable or aggressive histologic features of prostate cancer, resulting in use as a diagnostic PET imaging radiotracer and therapeutic target. Here, we discuss the methods to develop 225Ac-DOTA-J591, an α-labeled compound targeting an extracellular epitope of prostate-specific membrane antigen, which is currently being studied in early clinical trials. In addition, we review quality control, radiation safety measures, and clinical considerations before administration of this radioimmunotherapeutic agent.