PT  - JOURNAL ARTICLE
AU  - Issa A. Al-Shakhrah
AU  - Abdelatif AlSharif
AU  - Awni Taleb Abu sneineh
TI  - Comparison Between the Values of the Hepatic Uptake Rate Obtained by 2 Methods, Using Hepatobiliary Scintigraphy in Patients with Nonalcoholic Steatohepatitis
AID  - 10.2967/jnmt.109.067355
DP  - 2010 Mar 01
TA  - Journal of Nuclear Medicine Technology
PG  - 37--41
VI  - 38
IP  - 1
4099  - http://tech.snmjournals.org/content/38/1/37.short
4100  - http://tech.snmjournals.org/content/38/1/37.full
SO  - J. Nucl. Med. Technol.2010 Mar 01; 38
AB  - 99mTc-mebrofenin hepatobiliary scintigraphy has been introduced for the noninvasive assessment of liver function in the clinical setting and in experimental research. Methods: During a period of 2 y, 15 patients with fatty livers diagnosed as having nonalcoholic steatohepatitis underwent hepatobiliary scintigraphy using the radiopharmaceutical agent 99mTc-labeled mebrofenin. After intravenous administration of 85 MBq of 99mTc-mebrofenin, a dynamic image was acquired with the liver and heart in the field of view. In this study, a comparison between the values of hepatic uptake rate obtained by applying 2 methods in patients with nonalcoholic steatohepatitis—multiple-time graphical analysis (Gjedde–Patlak plot) and the differentiation between different regions of interest using hepatobiliary scintigraphy—was made. Results: The values of the uptake rate reveal that uptake obtained by applying the second method are significantly higher than that obtained by applying the first one (P = 0.001). A strong positive association (n = 15; r = 0.92; R2 = 0.84) was found between these measurements. From a Bland–Altman statistical test that was performed on the results we also found that 87% of the cases (13/15) were within 1.96 SD. Conclusion: The Gjedde–Patlak analysis method can be considered as an alternative technique to find and calculate the hepatic uptake rate.