@article {Al-Shakhrah37, author = {Issa A. Al-Shakhrah and Abdelatif AlSharif and Awni Taleb Abu sneineh}, title = {Comparison Between the Values of the Hepatic Uptake Rate Obtained by 2 Methods, Using Hepatobiliary Scintigraphy in Patients with Nonalcoholic Steatohepatitis}, volume = {38}, number = {1}, pages = {37--41}, year = {2010}, doi = {10.2967/jnmt.109.067355}, publisher = {Society of Nuclear Medicine}, abstract = {99mTc-mebrofenin hepatobiliary scintigraphy has been introduced for the noninvasive assessment of liver function in the clinical setting and in experimental research. Methods: During a period of 2 y, 15 patients with fatty livers diagnosed as having nonalcoholic steatohepatitis underwent hepatobiliary scintigraphy using the radiopharmaceutical agent 99mTc-labeled mebrofenin. After intravenous administration of 85 MBq of 99mTc-mebrofenin, a dynamic image was acquired with the liver and heart in the field of view. In this study, a comparison between the values of hepatic uptake rate obtained by applying 2 methods in patients with nonalcoholic steatohepatitis{\textemdash}multiple-time graphical analysis (Gjedde{\textendash}Patlak plot) and the differentiation between different regions of interest using hepatobiliary scintigraphy{\textemdash}was made. Results: The values of the uptake rate reveal that uptake obtained by applying the second method are significantly higher than that obtained by applying the first one (P = 0.001). A strong positive association (n = 15; r = 0.92; R2 = 0.84) was found between these measurements. From a Bland{\textendash}Altman statistical test that was performed on the results we also found that 87\% of the cases (13/15) were within 1.96 SD. Conclusion: The Gjedde{\textendash}Patlak analysis method can be considered as an alternative technique to find and calculate the hepatic uptake rate.}, issn = {0091-4916}, URL = {https://tech.snmjournals.org/content/38/1/37}, eprint = {https://tech.snmjournals.org/content/38/1/37.full.pdf}, journal = {Journal of Nuclear Medicine Technology} }