PT  - JOURNAL ARTICLE
AU  - Juan P. Gambini
AU  - Margarita Nuñez
AU  - Pablo Cabral
AU  - Martín Lafferranderie
AU  - Javier Noble
AU  - Eduardo Corchs
AU  - Ricardo D'Albora
AU  - Eduardo Savio
AU  - Lucía Delgado
AU  - Omar Alonso
TI  - Evaluation of Patients with Head and Neck Cancer by Means of <sup>99m</sup>Tc-Glucarate
AID  - 10.2967/jnmt.109.062927
DP  - 2009 Dec 01
TA  - Journal of Nuclear Medicine Technology
PG  - 229--232
VI  - 37
IP  - 4
4099  - http://tech.snmjournals.org/content/37/4/229.short
4100  - http://tech.snmjournals.org/content/37/4/229.full
SO  - J. Nucl. Med. Technol.2009 Dec 01; 37
AB  - Preliminary findings have suggested that 99mTc-glucarate has tumor-seeking properties. The purpose of this study was to explore the potential of this tracer to evaluate malignant head and neck tumors by means of SPECT/CT software fusion imaging. Methods: Eleven male patients with advanced head and neck carcinoma were included in the study: 9 with locally advanced disease and 2 with clinical suspicion of local relapse. Scanning started 3–6 h after the injection of 1,110 MBq of 99mTc-glucarate. Planar and SPECT images of the head, neck, and thorax were acquired. Three-dimensional images were also coregistered with CT. Results: We found 99mTc-glucarate uptake in all suspected lesions. SPECT/CT fusion imaging was helpful in all cases for topographically localizing the tracer foci. Conclusion: 99mTc-glucarate can be considered a potential tracer for the evaluation of patients with head and neck tumors.