TY - JOUR T1 - Evaluation of Patients with Head and Neck Cancer by Means of <sup>99m</sup>Tc-Glucarate JF - Journal of Nuclear Medicine Technology JO - J. Nucl. Med. Technol. SP - 229 LP - 232 DO - 10.2967/jnmt.109.062927 VL - 37 IS - 4 AU - Juan P. Gambini AU - Margarita Nuñez AU - Pablo Cabral AU - Martín Lafferranderie AU - Javier Noble AU - Eduardo Corchs AU - Ricardo D'Albora AU - Eduardo Savio AU - Lucía Delgado AU - Omar Alonso Y1 - 2009/12/01 UR - http://tech.snmjournals.org/content/37/4/229.abstract N2 - Preliminary findings have suggested that 99mTc-glucarate has tumor-seeking properties. The purpose of this study was to explore the potential of this tracer to evaluate malignant head and neck tumors by means of SPECT/CT software fusion imaging. Methods: Eleven male patients with advanced head and neck carcinoma were included in the study: 9 with locally advanced disease and 2 with clinical suspicion of local relapse. Scanning started 3–6 h after the injection of 1,110 MBq of 99mTc-glucarate. Planar and SPECT images of the head, neck, and thorax were acquired. Three-dimensional images were also coregistered with CT. Results: We found 99mTc-glucarate uptake in all suspected lesions. SPECT/CT fusion imaging was helpful in all cases for topographically localizing the tracer foci. Conclusion: 99mTc-glucarate can be considered a potential tracer for the evaluation of patients with head and neck tumors. ER -