RT Journal Article SR Electronic T1 Biology of Cancer and PET Imaging: Pictorial Review JF Journal of Nuclear Medicine Technology JO J. Nucl. Med. Technol. FD Society of Nuclear Medicine SP 81 OP 89 DO 10.2967/jnmt.121.263534 VO 50 IS 2 A1 Sarikaya, Ismet YR 2022 UL http://tech.snmjournals.org/content/50/2/81.abstract AB CE credit: For CE credit, you can access the test for this article, as well as additional JNMT CE tests, online at https://www.snmmilearningcenter.org. Complete the test online no later than June 2025. Your online test will be scored immediately. You may make 3 attempts to pass the test and must answer 75% of the questions correctly to receive Continuing Education Hour (CEH) credit. Credit amounts can be found in the SNMMI Learning Center Activity. SNMMI members will have their CEH credit added to their VOICE transcript automatically; nonmembers will be able to print out a CE certificate upon successfully completing the test. The online test is free to SNMMI members; nonmembers must pay $15.00 by credit card when logging onto the website to take the test.Development and spread of cancer is a multistep and complex process that involves a number of alterations, interactions, and molecular networks. PET imaging is closely related to cancer biology and pathology, as it uses various radiotracers targeting biologic and pathologic changes in cancer cells and the tumor microenvironment. In this review article, the biology of the development and spread of cancer and the role of PET imaging in oncology are summarized and supported by various PET images demonstrating patterns of cancer spread.