RT Journal Article
SR Electronic
T1 Is the Physical Decay Correction of the ^{18}F-FDG Input Function in Dynamic PET Imaging Justified?
JF Journal of Nuclear Medicine Technology
JO J. Nucl. Med. Technol.
FD Society of Nuclear Medicine
SP 111
OP 113
DO 10.2967/jnmt.108.060350
VO 37
IS 2
A1 Eric Laffon
A1 Olivier Barret
A1 Roger Marthan
A1 Dominique Ducassou
YR 2009
UL http://tech.snmjournals.org/content/37/2/111.abstract
AB In this theoretic note, the rationale for the physical decay correction of the 18F-FDG input function in dynamic PET is investigated, using the Patlak equation as an example. Methods: The Patlak equation conventionally obtained when correcting the 18F-FDG input function and correcting the tissue activity measurement for 18F physical decay can also be derived from a 2-compartment analysis that does not conceptually involve any physical decay correction of the 18F-FDG input function but accounts only for the physical decay of the trapped tracer. Results: We demonstrate that exactly the same equation can be derived from the 2 conceptual approaches, and hence each approach yields the correct uptake rate of the tracer. Conclusion: No advantage in 18F-FDG dynamic PET can be expected from using the concept of uncorrected data rather than that of decay-corrected data. Nevertheless, conceptually, we show that correcting the 18F-FDG input function for radioactive decay cannot be justified and that this correction is not compatible with the calculation of patient radiation dose.