RT Journal Article SR Electronic T1 Is the Physical Decay Correction of the 18F-FDG Input Function in Dynamic PET Imaging Justified? JF Journal of Nuclear Medicine Technology JO J. Nucl. Med. Technol. FD Society of Nuclear Medicine SP 111 OP 113 DO 10.2967/jnmt.108.060350 VO 37 IS 2 A1 Eric Laffon A1 Olivier Barret A1 Roger Marthan A1 Dominique Ducassou YR 2009 UL http://tech.snmjournals.org/content/37/2/111.abstract AB In this theoretic note, the rationale for the physical decay correction of the 18F-FDG input function in dynamic PET is investigated, using the Patlak equation as an example. Methods: The Patlak equation conventionally obtained when correcting the 18F-FDG input function and correcting the tissue activity measurement for 18F physical decay can also be derived from a 2-compartment analysis that does not conceptually involve any physical decay correction of the 18F-FDG input function but accounts only for the physical decay of the trapped tracer. Results: We demonstrate that exactly the same equation can be derived from the 2 conceptual approaches, and hence each approach yields the correct uptake rate of the tracer. Conclusion: No advantage in 18F-FDG dynamic PET can be expected from using the concept of uncorrected data rather than that of decay-corrected data. Nevertheless, conceptually, we show that correcting the 18F-FDG input function for radioactive decay cannot be justified and that this correction is not compatible with the calculation of patient radiation dose.