%0 Journal Article
%A Eric Laffon
%A Olivier Barret
%A Roger Marthan
%A Dominique Ducassou
%T Is the Physical Decay Correction of the ^{18}F-FDG Input Function in Dynamic PET Imaging Justified?
%D 2009
%R 10.2967/jnmt.108.060350
%J Journal of Nuclear Medicine Technology
%P 111-113
%V 37
%N 2
%X In this theoretic note, the rationale for the physical decay correction of the 18F-FDG input function in dynamic PET is investigated, using the Patlak equation as an example. Methods: The Patlak equation conventionally obtained when correcting the 18F-FDG input function and correcting the tissue activity measurement for 18F physical decay can also be derived from a 2-compartment analysis that does not conceptually involve any physical decay correction of the 18F-FDG input function but accounts only for the physical decay of the trapped tracer. Results: We demonstrate that exactly the same equation can be derived from the 2 conceptual approaches, and hence each approach yields the correct uptake rate of the tracer. Conclusion: No advantage in 18F-FDG dynamic PET can be expected from using the concept of uncorrected data rather than that of decay-corrected data. Nevertheless, conceptually, we show that correcting the 18F-FDG input function for radioactive decay cannot be justified and that this correction is not compatible with the calculation of patient radiation dose.
%U https://tech.snmjournals.org/content/jnmt/37/2/111.full.pdf