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OtherImaging (JNMT)

Immune checkpoint inhibitor related adverse effects and FDG PET/CT findings

Jan-Henning Schierz, Ismet Sarikaya, Uwe Wollina, Leonore Unger and Ali Sarikaya
Journal of Nuclear Medicine Technology July 2021, jnmt.121.262151; DOI: https://doi.org/10.2967/jnmt.121.262151
Jan-Henning Schierz
1 Municipal Hospital Dresden, Department of Radiology, Dresden, Germany;
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Ismet Sarikaya
2 Kuwait University Faculty of Medicine, Department of Nuclear Medicine, Kuwait, Kuwait;
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Uwe Wollina
3 Municipal Hospital Dresden, Department of Dermatology, Dresden, Germany;
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Leonore Unger
4 Municipal Hospital Dresden, Department of Rheumatology, Dresden, Germany;
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Ali Sarikaya
5 Trakya university Faculty of Medicine, Department of Nuclear Medicine, Turkey
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Abstract

Immune check-point inhibitor (ICI) treatments activate the T-cells against tumor. Activated T-cells not only attack the tumor but also healthy cells, causing an autoimmune reaction in various tissues. These immune related adverse effects (IRAE) cause 18F-fluorodeoxyglucose (FDG) uptake in various tissues due to inflammation. It is important to recognize and report these findings on FDG Positron Emission Tomography/Computed Tomography (PET/CT) studies. FDG PET helps to determine the presence, location and severity of IRAEs. In severe cases, ICI treatments are interrupted or suspended and anti-inflammatory treatments are started. FDG uptake due IRAEs may mimic metastases or disease progression. Their presence may also help predicting response to treatment and have prognostic implications. In this review article, we will provide basic information about ICI treatments, IRAEs and FDG PET/CT findings.

  • Oncology: General
  • PET
  • PET/CT
  • FDG PET/CT
  • Immune checkpoint inhibitor
  • adverse effect
  • autoimmune
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Journal of Nuclear Medicine Technology: 50 (4)
Journal of Nuclear Medicine Technology
Vol. 50, Issue 4
December 1, 2022
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Immune checkpoint inhibitor related adverse effects and FDG PET/CT findings
Jan-Henning Schierz, Ismet Sarikaya, Uwe Wollina, Leonore Unger, Ali Sarikaya
Journal of Nuclear Medicine Technology Jul 2021, jnmt.121.262151; DOI: 10.2967/jnmt.121.262151

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Immune checkpoint inhibitor related adverse effects and FDG PET/CT findings
Jan-Henning Schierz, Ismet Sarikaya, Uwe Wollina, Leonore Unger, Ali Sarikaya
Journal of Nuclear Medicine Technology Jul 2021, jnmt.121.262151; DOI: 10.2967/jnmt.121.262151
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Keywords

  • Oncology: General
  • PET
  • PET/CT
  • FDG PET/CT
  • immune checkpoint inhibitor
  • adverse effect
  • autoimmune
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