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OtherImaging (JNMT)

Fewer Angle SPECT/CT (FASpecT/CT) Blood Pool Imaging for Infection and Inflammation

William T. Phillips, Brandon C. Gorzell, Robert A. Martinez, Umber A. Salman, Albert W. Cooper, Derek J. Stocker and Chad C. Adams
Journal of Nuclear Medicine Technology December 2020, jnmt.120.256933; DOI: https://doi.org/10.2967/jnmt.120.256933
William T. Phillips
1 University of Texas Health Science Center San Antonio, United States;
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Brandon C. Gorzell
2 University of Texas Health Sciences Center San Antonio, United States;
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Robert A. Martinez
1 University of Texas Health Science Center San Antonio, United States;
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Umber A. Salman
1 University of Texas Health Science Center San Antonio, United States;
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Albert W. Cooper
1 University of Texas Health Science Center San Antonio, United States;
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Derek J. Stocker
3 Walter Reed National Military Medical Center, United States
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Chad C. Adams
3 Walter Reed National Military Medical Center, United States
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Abstract

Rationale: A new protocol for rapid SPECT/CT blood pool imaging consisting of fewer image angle acquisitions was evaluated for localization of focal sites of soft tissue inflammation, infection and osteomyelitis. Methods: Immediately following dynamic flow and standard planar blood pool imaging with 99mTc-MDP, fewer angle SPECT/CT (FASpecT/CT) was performed with a dual head gamma camera consisting of 6 steps over 360°, 12 total images with 30° separation between angles and 30 seconds per image requiring a total imaging time of approximately 3 minutes. Images were reconstructed using ordered subset expectation maximization (OSEM) iterative reconstruction. Prior to use in a patient-care setting, various FASpecT/CT acquisition protocols were modeled using a phantom to determine the minimum number of stops and stop duration required to produce a reliable image. Results: FASpecT/CT blood pool images provided excellent 3-dimensional localization of spine osteomyelitis, soft tissue infection of the foot and tendonitis of the hand and foot utilizing a 3 minute image acquisition time. FASpecT/CT acquisition protocol required 1.3-3.5 minutes including camera movement time. This was a reduction of 72-90% when compared to the time required for the standard 60 angle, 20 second SPECT/CT acquisition. Principal Conclusion: FASpecT/CT blood pool images help localize focal sites of hyperemia/inflammation which can increase exam sensitivity and specificity. Additionally, utilizing a FASpecT/CT imaging protocol decreases imaging time by up to 90%.

  • Image Processing
  • Infectious Disease
  • SPECT/CT
  • FASpecT
  • SPECT/CT
  • blood pool imaging
  • infection
  • inflammation

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Journal of Nuclear Medicine Technology: 48 (4)
Journal of Nuclear Medicine Technology
Vol. 48, Issue 4
December 1, 2020
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Fewer Angle SPECT/CT (FASpecT/CT) Blood Pool Imaging for Infection and Inflammation
William T. Phillips, Brandon C. Gorzell, Robert A. Martinez, Umber A. Salman, Albert W. Cooper, Derek J. Stocker, Chad C. Adams
Journal of Nuclear Medicine Technology Dec 2020, jnmt.120.256933; DOI: 10.2967/jnmt.120.256933

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Fewer Angle SPECT/CT (FASpecT/CT) Blood Pool Imaging for Infection and Inflammation
William T. Phillips, Brandon C. Gorzell, Robert A. Martinez, Umber A. Salman, Albert W. Cooper, Derek J. Stocker, Chad C. Adams
Journal of Nuclear Medicine Technology Dec 2020, jnmt.120.256933; DOI: 10.2967/jnmt.120.256933
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  • Multicenter study of quantitative SPECT imaging: reproducibility of 99mTc quantitation using a conjugated gradient minimization reconstruction algorithm
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Keywords

  • Image Processing
  • Infectious Disease
  • SPECT/CT
  • FASpecT
  • blood pool imaging
  • infection
  • inflammation
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