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Journal of Nuclear Medicine Technology

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OtherContinuing Education (Invitation Only)

PET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature review

Susana Isabel Lourenco Lopes, Sara Ferreira and Marco Caetano
Journal of Nuclear Medicine Technology December 2020, jnmt.120.249540; DOI: https://doi.org/10.2967/jnmt.120.249540
Susana Isabel Lourenco Lopes
1 Nottingham University Hospitals, United Kingdom;
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Sara Ferreira
2 Health School Dr. Lopes Dias, Portugal;
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Marco Caetano
3 Lisbon School of Health Technology-Polytechnic Institute of Lisbon, Portugal
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Abstract

Introduction: PET/CT combines the molecular with the anatomical level which, with the administration of a hypoxia-sensitive radiopharmaceutical, allows the evaluation of tissue oxygenation. Materials and Methods: The work consists of a systematic literature review, including electronic addresses, books and articles dated from July 1997 to December 2019. The aim of this work is to identify the best suited PET radiopharmaceuticals for the detection of cell hypoxia and recognize the benefits for treatment planning with IMRT/VMAT techniques. Results: Hypoxia affects the likelihood cure of head and neck tumors, thereby reducing the success rate. Radiopharmaceuticals such as 18F-FMISO, 18F-FETNIM and 18F-HX4 allow the delineation of hypoxic subvolumes within the target volume to optimize IMRT/VMAT treatment. Discussion: The identification of hypoxia areas with PET/CT imaging and subsequent treatment with IMRT/VMAT allows a possible radiation dose escalation in radioresistant subvolumes. Conclusion: There is a decrease in relapses and an increased likelihood of disease-free survival.

  • Molecular Imaging
  • Oncology: Head and neck
  • PET/CT
  • Radiopharmaceuticals
  • Head and Neck Tumours
  • Hypoxic cells
  • PET/CT
  • Radiotherapy
  • Treatment Planning

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Journal of Nuclear Medicine Technology: 48 (4)
Journal of Nuclear Medicine Technology
Vol. 48, Issue 4
December 1, 2020
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PET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature review
Susana Isabel Lourenco Lopes, Sara Ferreira, Marco Caetano
Journal of Nuclear Medicine Technology Dec 2020, jnmt.120.249540; DOI: 10.2967/jnmt.120.249540

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PET/CT in the evaluation of hypoxia for radiotherapy planning in head and neck tumors: systematic literature review
Susana Isabel Lourenco Lopes, Sara Ferreira, Marco Caetano
Journal of Nuclear Medicine Technology Dec 2020, jnmt.120.249540; DOI: 10.2967/jnmt.120.249540
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Keywords

  • Molecular Imaging
  • Oncology: Head and neck
  • PET/CT
  • Radiopharmaceuticals
  • Head and Neck Tumours
  • Hypoxic cells
  • Radiotherapy
  • Treatment Planning
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