Topical Device Detection of 18F FDG Dose Leakage

Abstract

PET and standard uptake value (SUV) depend on reliable pharmacokinetic modelling, part of which is predictable dose delivery. Partial extravasation of the intravenous dose administered undermines predictability of dose delivery and potentially the accuracy of the SUV calculation. Utilisation of the LARA device with topical sensors is a simple, non-invasive way to determine partial dose extravasation. As part of routine monitoring of 18F FDG PET administrations, an interesting case was identified that mimicked extravasation but represented dose leakage during infusion via an auto-injector. The LARA device provided a useful tool for more timely critical evaluation and problem solving; extending advantage to the patient and practice.